Department of Medicine

Publications

Original Articles (published or in press)

  • Gomez D, Al Haj Zen A, Borges LF, Philippe M, Gutierrez PS, Jondeau G, Michel JB, Vranckx R. Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway. Journal of Pathology. 2009 May; 218(1):131-42. https://doi.org/10.1002/path.2516; PubMed PMID: 19224541
  • Borges LF*, Gomez D*, Quintana M, Touat Z, Jondeau G, Leclercq A, Meilhac O, Jandrot-Perrus M, Gutierrez PS, Freymuller E, Vranckx R, Michel JB. Fibrinolytic activity is associated with presence of cystic medial degeneration in aneurysms of the ascending aorta. Histopathology. 2010 Dec;57(6):917-32. https://doi.org/10.1111/j.1365-2559.2010.03719.x; PubMed PMID: 21166705
    * denotes equal contribution
  • Gomez D, Coyet A, Ollivier V, Jeunemaitre X, Jondeau G, Michel JB, Vranckx R. Epigenetic control of vascular smooth muscle cells in Marfan and non-Marfan thoracic aortic aneurysms. Cardiovascular Research. 2011 Feb 1;89(2):446-56. https://doi.org/10.1093/cvr/cvq291; PubMed PMID: 20829218
  • Paloschi V, Kurtovic S, Folkersen L, Gomez D, Wågsäter D, Roy J, Petrini J, Eriksson MJ, Caidahl K, Hamsten A, Liska J, Michel JB, Franco-Cereceda A, Eriksson P. Impaired splicing of fibronectin is associated with thoracic aortic aneurysm formation in patients with bicuspid aortic valve. Arterioscler Thromb Vasc Biol. 2011 Mar;31(3):691-7. https://doi.org/10.1161/ATVBAHA.110.218461; PubMed PMID: 21148425
  • Baasanjav S, Al-Gazali L, Hashiguchi T, Mizumoto S, Fischer B, Horn D, Seelow D, Ali BR, Aziz SA, Langer R, Saleh AA, Becker C, Nürnberg G, Cantagrel V, Gleeson JG, Gomez D, Michel JB, Stricker S, Lindner TH, Nürnberg P, Sugahara K, Mundlos S, Hoffmann K. Faulty initiation of proteoglycan synthesis causes cardiac and joint defects. Am J Hum Genet. 2011 Jul 15;89(1):15-27. https://doi.org/10.1016/j.ajhg.2011.05.021; PubMed PMID: 21763480
  • Ho-Tin-Noé B, Le Dall J, Gomez D, Louedec L, Vranckx R, El-Bouchtaoui M, Legrès L, Meilhac O, Michel JB. Early Atheroma-Derived Agonists of Peroxisome Proliferator-Activated Receptor-g Trigger Intramedial Angiogenesis in a Smooth Muscle Cell-Dependent Manner. Circulation Research. 2011 Oct 14;109(9):1003-14. https://doi.org/10.1161/CIRCRESAHA.110.235390; PubMed PMID: 21885829
  • Salmon M, Gomez D, Greene E, Shankman L, Owens GK. Cooperative Binding of KLF4, pELK-1, and HDAC2 to a G/C Repressor Element in the SM22α Promoter Mediates Transcriptional Silencing During SMC Phenotypic Switching In Vivo. Circulation Research. 2012 Aug 31;111(6):685-96. https://doi.org/10.1161/CIRCRESAHA.112.269811; PubMed PMID: 22811558
    • Editorial: Modulation of Smooth Muscle Cell Phenotype: The Other Side of the Story. Jianhe Huang and Michael S. Parmacek. Circulation Research. 2012;111:659-661
  • Gomez D, Richard B, Borges LF, Ollivier V, Mansilla S, Kessler K, Alkoder S, Nataf P, Jandrot-Perrus M, Bouton MC, Jondeau G, Vranckx R, Michel JB. Smad2-dependent PN-1 overexpression differentiates progressively dilating aneurysms from acute dissections of the ascending aorta in human. Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2222-32. https://doi.org/10.1161/ATVBAHA.113.301327; PubMed PMID: 23814118
  • Gomez D, Kessler K, Michel JB, Vranckx R. Modifications of chromatin dynamics control Smad2 pathway activation in aneurysmal smooth muscle cells. Circulation Research. 2013; 113: 881-890. https://doi.org/10.1161/CIRCRESAHA.113.301989; PubMed PMID: 23825360
    • Editorial: Forgetting to Switch Off SMAD2 in Aneurysmal Disease. Amy Leung, Rama Natarajan. Circulation Research. 2013; 113: 843-845
  • Gomez D, Shankman S, Nguyen AT, Owens GK. Detection of Histone Modifications of Specific Gene Loci in Single Cells in Histological Sections. Nature Methods. 2013; 10:171–177. https://doi.org/10.1038/nmeth.2332; PubMed PMID: 23314172
    • This paper has been highlighted in 10+ articles and scientific blogs including:
      • A third-generation method reveals cell lineage ancestry. Feinberg AP. Nature Methods. 2013; 10, 117–118.
      • Modus Operandi: Precision Epigenetics. The Scientist. Sept 2013.
      • F1000Prime Recommendation. Faculty of 1000. Mar 2013.
      • Lab Tools: Pushing the Limits. The Scientist. Feb 2015.
  • Shankman L, Gomez D, Cherepanova O, Salmon M, Alencar GF, Haskins RM, Swiatlowska P, Newman AAC, Greene ES, Straub AC, Isakson B, Randolph GJ, Owens GK. KLF4-dependent phenotypic modulation of smooth muscle cells has key role in atherosclerotic plaque pathogenesis. Nature Medicine. 2015 Jun;21(6):628-37. https://doi.org/10.1038/nm.3866; PubMed PMID: 25985364
    • Editorial: Converting smooth muscle cells to macrophage-like cells with KLF4 in atherosclerotic plaques. Rosenfeld ME. Nature Medicine. 2015 Jun 4;21(6):549-51. doi: 10.1038/nm.3875.
  • Cherepanova OA, Gomez D, Shankman LS, Swiatlowska P, Williams J, Sarmento OF, Alencar GF, Bevard MH, Greene ES, Murgai M, Turner SD, Geng YJ, Connelly JJ, Bekiranov S, Tomilin A, Owens GK. Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective. Nature Medicine. 2016 Jun;22(6):657-65. https://doi.org/10.1038/nm.4109; PubMed PMID: 27183216
  • Durgin BG, Cherepanova OA, Gomez D, Karaoli T, Alencar GF, Butcher JT, Zhou YQ, Bendeck MP, Isakson BE, Owens GK, Connelly JJ. Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions. Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H943-H958. https://doi.org/10.1152/ajpheart.00029.2017; PubMed PMID: 28283548
  • Gomez D, Baylis RA, Durgin BG, Newman AAC, Alencar GF, Mahan S, St. Hilaire C, Muller W, Waisman A, Francis SE, Pinteaux E, Randolph GJ, Gram H, Owens GK. Interleukin-1β promotes atheroprotective effects of advanced atherosclerotic lesions in mice. Nature Medicine. 2018 Sep;24(9):1418-1429. https://doi.org/10.1038/s41591-018-0124-5; PubMed PMID: 30038218
  • Mahan S, Liu M, Baylis RA, Gomez D. Quantitative analysis of cellular composition in advanced atherosclerotic lesions of smooth muscle cell lineage tracing mice. J Vis Exp. 2019 Feb 20;(144):10.3791/59139. https://dx.doi.org/10.3791/59139; PubMed PMID: 30855565
  • Moorhead W III, Chu C, Cuervas RA, Callahan J IV, Wong R, Regan C, Boufford CK, Sur S, Liu M, Gomez D, MacTaggart JN, Kamenskiy A, Boehm M, St Hilaire C. Dysregulation of FOXO1 (Forkhead Box O1 Protein) Drives Calcification in Arterial Calcification due to Deficiency of CD73 and Is Present in Peripheral Artery Disease. Arterioscler Thromb Vasc Biol. 2020 Jul;40(7):1680-1694. https://doi.org/10.1161/ATVBAHA.119.313765; PubMed PMID: 32375544
  • Demirdelen S, Mannes PZ, Mubin Aral A, Haddad J, Leers SA, Gomez D, Tavakoli Sina. Divergence of Acetate Uptake in Proinflammatory and Inflammation-Resolving Macrophages: Implications for Imaging Atherosclerosis. Journal of Nuclear Cardiology. 2021 Jan 8. https://doi.org/10.1007/s12350-020-02479-5; PubMed PMID: 33420659
  • Satoh T, Wang L, Espinosa-Diez C, Wang B, Hahn SA, Noda K, Rochon ER, Dent MR, Levine AR, Baust JJ, Wyman S, Wu YL, Triantafyllou  GA, Tang Y, Reynolds M, Shiva S, St Hilaire C, Gomez D, Goncharov DA, Goncharova EA, Chan SY, Straub AC, Lai YC, McTiernan CF, Gladwin MT. Metabolic syndrome mediates ROS-miR-193b-NFYA-dependent down regulation of sGC activity and contributes to exercise-induced pulmonary hypertension in HFpEF. Circulation. 2021 Aug 24;144(8):615-637. doi: 10.1161/CIRCULATIONAHA.121.053889; PubMed PMID: 34157861
  • Liu M, Espinosa-Diez C, Mahan S, Du M, Nguyen AT, Hahn S, Chakraborty R, Straub AC, Martin KA, Owens GK, Gomez D. H3K4 di-methylation controls smooth muscle cell epigenetic memory, lineage identity and vascular homeostasis. Developmental Cell. 2021 Oct 11;56(19):2765-2782.e10. doi: 10.1016/j.devcel.2021.09.001. PubMed PMID: 34582749
  • Galley JC, Miller MP, Sanker S, Liu M, Sharina I, Martin E, Gomez D, Straub AC. FoxO4 regulates sGCb transcription in vascular smooth muscle. Am J Physiol Heart Circ Physiol. 2022 Mar 1;322(3):H417-H426. doi: 10.1152/ajpheart.00551.2021. PubMed PMID: 35089807
  • Espinosa-Diez C, Mandi V, Du M, Liu M, Gomez D. Clones but not carbon copies: phenotypic and functional diversity of smooth muscle cell in atherosclerosis. Journal of Vascular Surgery – Vascular Science. May 14, 2021. doi: 10.1016/j.jvssci.2021.02.002. PubMed PMID: 34617064
  • Zhang H, Bouman Chen Z, Fredman G, Gomez D, Grumbach IM, Huang NF, Nguyen P, Ouimet M, Sutton NR, Aikawa. What Makes a Great Mentor: Interviews With Recipients of the ATVB Mentor of Women Award. Arterioscler Thromb Vasc Biol. 2021 Sep 22; 41:2641–2647. doi.org/10.1161/ATVBAHA.121.316558. PubMed PMID: 34547925 
  • Bhuiyan MIH, Young CB, Jahan I, Liu M, Chattopadhyay A, Huang H, Kahle K, Zhang J, Poloyac SM, Molyneaux BJ, Straub AC, Deng X, Gomez D, Sun D. NF-kB signaling-mediated activation of WNK-SPAK-NKCC1 cascade in worsened outcomes from stroke comorbid hypertension. Stroke. 2022 Mar 11; doi.org/10.1161/STROKEAHA.121.038351. PubMed PMID: 35272484 
  • Du M, Espinosa-Diez C, Liu M, Ahmed IA, Mahan S, Wei J, Handen AL, Chan SY, Gomez D. miRNA/mRNA co-profiling identifies the miR-200 family as a central regulator of SMC quiescence. iScience. Volume 25, Issue 5, 20 May 2022, 104169. doi: 10.1016/j.isci.2022.104169. PubMed PMID: 35465051 

Review Articles

  • Liu M, Gomez D. Smooth Muscle Cell phenotypic diversity: At the crossroads of lineage tracing and single-cell transcriptomics. Arterioscler Thromb Vasc Biol. 2019 Sep;39(9):1715-1723. https://doi.org/10.1161/ATVBAHA.119.312131; PubMed PMID: 31340668
  • Espinosa-Diez C, Mandi V, Du M, Liu M, Gomez D. Clones but not carbon copies: phenotypic and functional diversity of smooth muscle cell in atherosclerosis. Invited review. Journal of Vascular Surgery – Vascular Science. In press

Editorials and Commentaries

  • Nguyen AT, Gomez D, Bell RD, Campbell JH, Clowes AW, Gabbiani G, GiachelliCM, Parmacek MS, Raines EW, Rusch NJ, Speer MY, Sturek M, Thyberg J, Towler DA, Weiser-Evans MC, Yan C, Miano JM, Owens GK. Smooth Muscle Cell Plasticity: Fact or Fiction? Circulation Research. 2013 Jan 4;112(1):17-22. https://doi.org/10.1161/CIRCRESAHA.112.281048; PubMed PMID: 23093573
  • Baylis RA, Gomez D, Mallat Z, Pasterkamp G, Owens GK. The CANTOS Trial: One Important Step for Clinical Cardiology but a Giant Leap for Vascular Biology. Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):e174-e177. https://doi.org/10.1161/ATVBAHA.117.310097; PubMed PMID: 28970294
  • Dutta P, Gomez D, Gladwin MT. Do BRD(4)S of a feather flock together? How an inflammation driven epigenetic regulator may link pulmonary hypertension and coronary artery disease. Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1428-1430. https://doi.org/10.1161/ATVBAHA.117.309632; PubMed PMID: 28747456
  • Bonnet S, Gomez D. RNA methylation: a new regulator of vascular remodeling in pulmonary hypertension. Am J Respir Crit Care Med. 2021 May 1;203(9):1060-1062. 2021 May 1;203(9):1060-1062. https://doi.org/10.1164/rccm.202011-4185ED; PubMed PMID: 33636090

Books and Chapters

  • Gomez D. Epigenetic reprogramming of aortic Smooth Muscle Cells: Application to the aneurysmal remodeling. European University Editions. In French.
  • Lacolley P, Michel JB, Gomez D, Bäck M, Regnault V. Vascular smooth muscle cell dysfunction and arterial stiffness. Book chapter in Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease. 2020.