The Gomez lab studies the functional role of epigenetic and transcriptional mechanisms controlling fundamental properties of vascular smooth muscle cells. Using a multi-scale approach of epigenomic (Cut&Tag, ATACseq), transcriptomic (RNAseq), and functional studies, we aim to investigate the causal relationship between the establishment of lineage-specific chromatin states or non-coding RNA signatures and the maintenance of vascular cell identity and functions. Alteration of vascular smooth muscle cell phenotype plays a major in the development and progression of common vascular diseases, accounting for most of the deaths in the United States and worldwide, including atherosclerosis and coronary artery disease, hypertension, peripheral artery disease, and aortic disease. The Gomez Lab aspires to characterize disease-associated epigenetic and nuclear alterations and identify relevant targeting approaches to revert and reprogram phenotypically modulated vascular smooth muscle cells. The Gomez Lab is part of the Vascular Medicine Institute (VMI) at the University of Pittsburgh-School of Medicine which provides a vibrant and stimulating research environment. VMI has a strong training program for outstanding postdoctoral scholars and graduate students aspiring to make a career in vascular biology. Candidates interested in learning more about our research and joining the Gomez Lab are encouraged to contact Dr. Gomez by email at email@example.com.